Pharmaceutical Chemistry: Role of Pharmaceutical Chemistry in the Development of Drug Compound

Pharmaceutical chemistry is the study of drug compounds, and it involves drug development process. This includes drug discovery, delivery, absorption, metabolism, distribution and excretion. There are elements of biomedical analysis, pharmacology, pharmacokinetics, and pharmacodynamics. Pharmaceutical chemistry work is usually done in laboratory conditions it mainly involves cures and remedies for disease, analytical techniques, pharmacology, metabolism, quality control, quality assurance, and drug chemistry. Pharmaceutical chemistry leads to careers in drug development, pharmaceutical industries and research facilities. Pharmaceutical chemists are involved in the development and assessment of therapeutic compounds. Every chemical that is synthesized must be tested for biological activity. In vitro testing involves biological assays outside a living system that means in a laboratory conditions.

For example, if the desired effect of a drug is to inhibit a particular enzyme, the enzyme can be isolated from an organ and studied in a test tube. New technologies have made it possible to assay large numbers of compounds in a short period. High-throughput drug screening allows pharmaceutical chemists to test between 100 and 100,000 chemicals in a single day. A compound will undergo further tests, or it may be chemically modified to enhance its biological activity.

The field of pharmaceutical chemistry is unique and it involves vast areas of expertise. Analytical chemists can isolate and identify active components from plant and other natural resources. Pharmaceutical chemists evaluate the bioactivity of drugs and drug metabolites. Pharmacologists can assess drug purity, safety and efficacy adverse effects of drug therapy. When a drug has been approved for human studies, clinicians and physicians should monitor patient’s compliance to treatment with the new drug compound. 

The impact of pharmaceutical chemistry in development of drug compounds is very high and advanced methods are now available for development of the drug by using pharmaceutical chemistry are:

CORE COMPETENCIES IN PHARMACEUTICAL CHEMISTRY:

•             Molecular modelling based drug design system

•             Advanced organic synthesis techniques

•             In-vitro safety studies

•             Analytical method development

•             Metabolic stability studies

•             Screening of drug candidates and lead molecules

To know about Pharmaceutical Chemistry Follow given link: 

https://bioorganic-medicinal.chemistryconferences.org/