Combining drugs and the future
Drug combinations alter the effectiveness of
antibiotics
The
efficiency of antibiotics might be altered by combining them with each other,
non-antibiotic drugs or else even with food additives. Depending on the
bacterial species, a few combinations stop antibiotics from functioning to
their complete capacity as others begin to overcome antibiotic resistance.
Succeeding antibiotic
resistance
Overuse
and misuse of antibiotics have led to significant antibiotic resistance. Particular
combinations of drugs can assist in preventing multi-drug resistant bacterial infections;
however, they may be largely unexplored and infrequently utilized in clinics
Though
most of the examined drug combinations reduced the antibiotics’ effect, there
were over 500 drug combinations which improved the antibiotic effect. These
positive pairings also examined in multi-drug resistant bacteria, they have
been found to improve antibiotic effects.
When
vanillin - the compound that gives vanilla its exclusive taste - became paired
with one specific antibiotic called spectinomycin, it helped the antibiotic to
enter bacterial cells and inhibit their growth. Spectinomycin is rarely used
these days because of the bacterial resistance that was developed against it.
Pairings this may increase
the arsenal of weapons in the war against antibiotic resistance.
However,
vanillin lessened the effect of many different kinds of antibiotics. Vanillin
works in a similar manner to aspirin to reduce many antibiotic actions - even
though its results in human cells have not been examined, they’re most likely
different.
According
to researchers, combinations of drugs that lower the effect of antibiotics may
also be beneficial to human health. Antibiotics can cause collateral damage and
side effects because they target healthy bacteria as well. However, the effects
of these drug combinations are particularly selective, and often only affect
some bacterial species. In the future, we might utilize drug combinations to
specifically stop the harmful impacts of antibiotics on healthy bacteria. This
will also decrease antibiotic resistance development, as healthy bacteria might
not be sited under pressure to develop antibiotic resistance that might
afterward be transferred to harmful bacteria.
For more details
visit: https://bioorganic-medicinal.chemistryconferences.org
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