Sunday 24 June 2018

Application of Flow Chemistry in Medicinal Chemistry Programmes

The Pharmaceutical Sciences department focuses mainly on the discovery and characterization of synthetic and natural bioactive compounds, and the improvement of pharmaceutical formulations to enhance the pharmacokinetics and pharmacodynamics of lead compounds.

Only a few laboratories are especially interested in steroid chemistry and receptors and have experience in the implementation of enabling technology – including flow chemistry – to assist complicated syntheses, generation of lead-like compound libraries and large-scale compound preparation.


One of the most vital features of the modular Asia system to diversify our flow equipment is the extraordinarily smooth and precise flow achieved by using the Asia pump, even at the low flow rates we use in our approaches. it is also definitely beneficial for compound library generation, screening reactions and optimization research, as it is easy to work with small quantities of the compound, that is crucial when you work with expensive substances, including enzymes.
Researchers are very pleased with the Asia system; it is every bit as excellent as they predicted and wonderful to be able to translate biosynthetic steroid pathways into continuous flow processes to expedite early drug discovery.

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