tag:blogger.com,1999:blog-14183568581352071832024-03-13T02:37:25.767-07:00World Congress on Bioorganic and Medicinal ChemistryNovember 22-23, 2019 | Dubai, UAE
Theme: Shaping the Future of Bioorganic and Medicinal ChemistryBioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.comBlogger36125tag:blogger.com,1999:blog-1418356858135207183.post-61050299191063222552018-11-30T01:24:00.000-08:002018-11-30T01:26:54.963-08:00Shaping the Future of Bioorganic and Medicinal Chemistry<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="font-size: 12.0pt; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin;"><b><a href="https://bioorganic-medicinal.chemistryconferences.org/conference-brochure.php">ME Conferences</a></b> takes a lot of privilege to welcome all the scholars and researchers from all around the world to expatiate about their respective scientific research at 2nd World Congress on Bioorganic and Medicinal Chemistry which is CPD accredited<b>.<o:p></o:p></b></span></div>
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<b><span style="font-size: 12.0pt; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin;">2<sup>nd</sup> World Congress on Bioorganic and Medicinal Chemistry</span></b><span style="font-size: 12.0pt; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin;"> scheduled on </span><span style="font-size: 12.0pt;">November 22-23</span><span style="font-size: 12.0pt; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin;">, 2019 Dubai, UAE goes with the theme <i>Shaping the Future of Bioorganic and Medicinal Chemistry</i>. <a href="https://bioorganic-medicinal.chemistryconferences.org/abstract-submission.php"><b>Bioorganic Medicinal 2019</b></a> is an international event focusing on the core knowledge and major advances in the ever-expanding field of Bioorganic and Medicinal Chemistry by attracting experts on a global scale. It is a global platform to discuss the innovative researches and developments in the Bioorganic and Medicinal Chemistry. It is a golden opportunity to meet eminent personalities and to learn the latest technological advancements. <o:p></o:p></span></div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjWEWnKrVPbkXt-TOr_xNLyGLNHujnvclcU0P4A71w2uYeLc4a4VvBYcVTY1aUN-9m0seoN07sOtuxLxE3xcTA7WP6l1lcP2nuJUSqZ_RnJgC5WwAmH5ZK7yIMDYDI3KakmFyKypJu_qZs/s1600/Bioorganic2019.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="512" data-original-width="1024" height="200" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjWEWnKrVPbkXt-TOr_xNLyGLNHujnvclcU0P4A71w2uYeLc4a4VvBYcVTY1aUN-9m0seoN07sOtuxLxE3xcTA7WP6l1lcP2nuJUSqZ_RnJgC5WwAmH5ZK7yIMDYDI3KakmFyKypJu_qZs/s400/Bioorganic2019.png" width="400" /></a></div>
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<span style="font-size: 12.0pt; line-height: 115%; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;">The distinctive features of the conference includes<o:p></o:p></span></div>
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<!--[if !supportLists]--><span lang="EN-US" style="font-family: "symbol"; font-size: 12.0pt;">·<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;"> </span></span><!--[endif]--><span lang="EN-US" style="font-size: 12.0pt; mso-ansi-language: EN-US;">Agro Chemistry<o:p></o:p></span></div>
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<!--[if !supportLists]--><span lang="EN-US" style="font-family: "symbol"; font-size: 12.0pt;">·<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;"> </span></span><!--[endif]--><span lang="EN-US" style="font-size: 12.0pt; mso-ansi-language: EN-US;">Analytical Chemistry<o:p></o:p></span></div>
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<!--[if !supportLists]--><span lang="EN-US" style="font-family: "symbol"; font-size: 12.0pt;">·<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;"> <a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/biochemistry"> </a></span></span><!--[endif]--><span lang="EN-US" style="font-size: 12.0pt; mso-ansi-language: EN-US;"><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/biochemistry">Biochemistry</a><o:p></o:p></span></div>
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<!--[if !supportLists]--><span lang="EN-US" style="font-family: "symbol"; font-size: 12.0pt;">·<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;"> </span></span><!--[endif]--><span lang="EN-US" style="font-size: 12.0pt; mso-ansi-language: EN-US;">Biological Drug Targets<o:p></o:p></span></div>
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<!--[if !supportLists]--><span lang="EN-US" style="font-family: "symbol"; font-size: 12.0pt;">·<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;"> </span></span><!--[endif]--><span lang="EN-US" style="font-size: 12.0pt; mso-ansi-language: EN-US;">Bioorganic Chemistry<o:p></o:p></span></div>
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<!--[if !supportLists]--><span lang="EN-US" style="font-family: "symbol"; font-size: 12.0pt;">·<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;"> </span></span><!--[endif]--><span lang="EN-US" style="font-size: 12.0pt; mso-ansi-language: EN-US;">Chemical Biology<o:p></o:p></span></div>
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<!--[if !supportLists]--><span lang="EN-US" style="font-family: "symbol"; font-size: 12.0pt;">·<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;"> </span></span><!--[endif]--><span lang="EN-US" style="font-size: 12.0pt; mso-ansi-language: EN-US;">Computational Chemistry<o:p></o:p></span></div>
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<!--[if !supportLists]--><span lang="EN-US" style="font-family: "symbol"; font-size: 12.0pt;">·<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;"> </span></span><!--[endif]--><span lang="EN-US" style="font-size: 12.0pt; mso-ansi-language: EN-US;">Drug Discovery, Design and Development<o:p></o:p></span></div>
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<!--[if !supportLists]--><span lang="EN-US" style="font-family: "symbol"; font-size: 12.0pt;">·<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;"> </span></span><!--[endif]--><span lang="EN-US" style="font-size: 12.0pt; mso-ansi-language: EN-US;">Environmental Chemistry<o:p></o:p></span></div>
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<!--[if !supportLists]--><span lang="EN-US" style="font-family: "symbol"; font-size: 12.0pt;">·<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;"> </span></span><!--[endif]--><span lang="EN-US" style="font-size: 12.0pt; mso-ansi-language: EN-US;">Green Chemistry<o:p></o:p></span></div>
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<!--[if !supportLists]--><span lang="EN-US" style="font-family: "symbol"; font-size: 12.0pt;">·<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;"> </span></span><!--[endif]--><span lang="EN-US" style="font-size: 12.0pt; mso-ansi-language: EN-US;"><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/medicinal-chemistry">Medicinal Chemistry</a><o:p></o:p></span></div>
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<!--[if !supportLists]--><span lang="EN-US" style="font-family: "symbol"; font-size: 12.0pt;">·<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;"> </span></span><!--[endif]--><span lang="EN-US" style="font-size: 12.0pt; mso-ansi-language: EN-US;">Molecular Biology<o:p></o:p></span></div>
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<!--[if !supportLists]--><span lang="EN-US" style="font-family: "symbol"; font-size: 12.0pt;">·<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;"> </span></span><!--[endif]--><span lang="EN-US" style="font-size: 12.0pt; mso-ansi-language: EN-US;">Nanochemistry<o:p></o:p></span></div>
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<!--[if !supportLists]--><span style="font-family: "symbol"; font-size: 12.0pt;">·<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;"> </span></span><!--[endif]--><span lang="EN-US" style="font-size: 12.0pt; mso-ansi-language: EN-US;">Pharmacokinetics & Pharmacodynamics</span><span style="font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;"><o:p></o:p></span></div>
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<span style="font-size: 12.0pt; line-height: 115%;">For more details visit our <a href="https://bioorganic-medicinal.chemistryconferences.org/">website</a></span></div>
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<span style="font-size: 12.0pt; line-height: 115%;">If you want to be a part of this esteemed event drop a mail at </span><a href="mailto:bioorganicmedicinalchemistry@gmail.com"><span style="font-size: 12.0pt; line-height: 115%;">bioorganicmedicinalchemistry@gmail.com</span></a><span style="font-size: 12.0pt; line-height: 115%;"><o:p></o:p></span></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-11629722577079218122018-11-25T22:51:00.001-08:002018-11-25T22:52:57.953-08:00World Congress on Bioorganic and Medicinal Chemistry<div dir="ltr" style="text-align: left;" trbidi="on">
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We gratefully thank all our wonderful Speakers, Conference Attendees, Students, Media Partners, and Associations for making Bioorganic Medicinal 2018 Conference the best ever!</div>
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The <span style="box-sizing: border-box; font-weight: 700;"><a href="https://bioorganic-medicinal.chemistryconferences.org/2018" style="background-color: transparent; box-sizing: border-box; color: #b98642; text-decoration-line: none;">World Congress on Bioorganic and Medicinal Chemistry</a></span>, hosted by the <span style="box-sizing: border-box; font-weight: 700;">ME Conferences</span> was held during <span style="box-sizing: border-box; font-weight: 700;">November 12-13, 2018</span> at <span style="box-sizing: border-box; font-weight: 700;">Dubai, UAE</span> based on the theme “<em style="box-sizing: border-box;">Explore the latest trends in Bioorganic and Medicinal Chemistry</em>".</div>
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Benevolent response and active participation were received from the Organizing Committee Members along with Scientists, Researchers, Students and leaders from various fields of Bioorganic and Medicinal Chemistry, Pharmaceutical Sciences and Medicine, who made this event a grand success.</div>
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ME Conferences expresses its gratitude to the conference Moderator, namely <span style="box-sizing: border-box; font-weight: 700;">Sara Hamzeh, University of Montreal, Canada</span> for taking up the responsibility to coordinate during the sessions. We are indebted to your support.</div>
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The conference was initiated with the Honourable presence of the Keynote forum.</div>
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<span style="box-sizing: border-box; font-weight: 700;">S L Nasa, Indian Hospital Pharmacists Association, India</span></div>
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The meeting reflected various sessions, in which discussions were held on the following major scientific tracks:</div>
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<em style="box-sizing: border-box;">Bioorganic and Medicinal Chemistry</em></div>
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<em style="box-sizing: border-box;">Pharmaceutical Chemistry</em></div>
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<em style="box-sizing: border-box;">Structural & Medicinal Biochemistry</em></div>
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<li style="box-sizing: border-box;"><div style="box-sizing: border-box; margin-bottom: 10px;">
<em style="box-sizing: border-box;">Biological Drug Targets</em></div>
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<em style="box-sizing: border-box;">Drug Design, Discovery and Development</em></div>
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<em style="box-sizing: border-box;">Drug delivery Techniques</em></div>
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<em style="box-sizing: border-box;">New Trends in Medicinal pharmacy</em></div>
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<em style="box-sizing: border-box;">Global Chemical Analysis</em></div>
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<em style="box-sizing: border-box;">Organic Chemistry in Today’s Life</em></div>
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<em style="box-sizing: border-box;">Medicinal Chemistry</em></div>
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<em style="box-sizing: border-box;">Pharmacokinetics & Pharmacodynamics</em></div>
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<em style="box-sizing: border-box;">Organic Chemical Engineering</em></div>
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<em style="box-sizing: border-box;">Medicinal Biochemistry</em></div>
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<em style="box-sizing: border-box;">Computational Chemistry</em></div>
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<em style="box-sizing: border-box;">Chemical Biology</em></div>
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We are also obliged to various experts, company representatives and other eminent scientists who supported the conference by facilitating the discussion forums. We sincerely thank the Organizing Committee Members for their gracious presence, support, and assistance.</div>
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With the grand success of Bioorganic and Medicinal Chemistry Congress 2018, ME Conferences would like to proudly announce the commencement of <a href="https://bioorganic-medicinal.chemistryconferences.org/" style="background-color: transparent; box-sizing: border-box; color: #b98642; text-decoration-line: none;"><span style="box-sizing: border-box; font-weight: 700;">2<span style="box-sizing: border-box; font-size: 9.75px; line-height: 0; position: relative; top: -0.5em; vertical-align: baseline;">nd</span> World Congress on Bioorganic and Medicinal Chemistry</span></a> to be organized during <span style="box-sizing: border-box; font-weight: 700;">November 22-23, 2019</span> at <span style="box-sizing: border-box; font-weight: 700;">Dubai, UAE</span>.</div>
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<em style="box-sizing: border-box;">Mark your calendars for the upcoming Conference; we are hopeful to see you soon!</em></div>
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More Info: <a href="https://bioorganic-medicinal.chemistryconferences.org/" style="background-color: transparent; box-sizing: border-box; color: #b98642; text-decoration-line: none;">https://bioorganic-medicinal.chemistryconferences.org/</a></div>
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<span style="box-sizing: border-box; font-weight: 700;"><em style="box-sizing: border-box;">If you are interested!</em></span></div>
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Email us at: <a href="mailto:medicinalchemistry@pharmameet.org" style="background-color: transparent; box-sizing: border-box; color: #b98642; text-decoration-line: none;">medicinalchemistry@pharmameet.org</a></div>
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Call at: 1-201-380-5561 (Ext. No- 7014)</div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-64220115966821961752018-10-14T22:26:00.000-07:002018-10-14T22:26:04.369-07:00What will be the Future of Antimicrobials?<div dir="ltr" style="text-align: left;" trbidi="on">
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<i><span style="color: #333333; font-size: 13.5pt;">Bacterial resistant- This study may aid in preventing antibacterial resistance!!<o:p></o:p></span></i></div>
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<span style="color: #333333; font-family: "Calibri","sans-serif"; font-size: 13.5pt; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;"><b><i>Bacteria</i></b> are microscopic
single-celled organisms. It consists of a single cell with a simple internal
structure. Most of the bacteria are harmless and beneficial. Only a few species
are harmful and cause diseases. <a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/pharmaceutical-chemistry"><b>Antimicrobials</b></a>
are the agent that kills or prevent the growth of microorganisms such as
bacteria, viruses or fungi. Nowadays bacteria are rapidly evolving and becoming<b>
resistant</b> to these antimicrobials.<o:p></o:p></span></div>
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<span style="color: #333333; font-family: "Calibri","sans-serif"; font-size: 13.5pt; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;">The new materials
researchers have designed and built allow antibacterial to be more potent and
have the ability to wipe out bacteria at smaller concentrations than the antibacterial
can do on their own. Scientists have discovered a <a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/drug-delivery-techniques">new
drug delivery system</a> that may help prevent bacterial infections.<o:p></o:p></span></div>
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<span style="color: #333333; font-family: "Calibri","sans-serif"; font-size: 13.5pt; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;">The researchers
synthesised <b>nanostructured silica particles</b>, considered to be promising drug
carriers, that contained payloads of an antimicrobial agent.<o:p></o:p></span></div>
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<span style="color: #333333; font-family: "Calibri","sans-serif"; font-size: 13.5pt; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;">According to the
previous study, they found that the particles were effective at killing two
human bacterial pathogens.<o:p></o:p></span></div>
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<span style="color: #333333; font-family: "Calibri","sans-serif"; font-size: 13.5pt; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;">While <a href="https://bioorganic-medicinal.chemistryconferences.org/conference-brochure.php">antibiotics</a>
are taken orally and that they become extensively distributed throughout the
body. But the new mechanism allows compounds to slowly release antimicrobials
into local environments, resulting in high amounts of the molecule in a
specific location. <o:p></o:p></span></div>
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<span style="color: #333333; font-family: "Calibri","sans-serif"; font-size: 13.5pt; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;">Interestingly, the
particles were more effective at killing the bacteria which may highlight a
more efficient mechanism for drug delivery.<o:p></o:p></span></div>
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<span style="color: #333333; font-family: "Calibri","sans-serif"; font-size: 13.5pt; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;">This is because the
newly designed <a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/new-trends-in-medicinal-pharmacy">nanomaterials</a>
allow the antibacterial to be localised, released slowly and attack the
microorganism more effectively<o:p></o:p></span></div>
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<span style="color: #333333; font-family: "Calibri","sans-serif"; font-size: 13.5pt; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;">Researchers said
the study could lead to the development of new microscopic particles containing
drugs, antiseptics or pesticides that may increase the effectiveness of the
therapy and <b>aid in preventing antibacterial resistance</b>. <o:p></o:p></span></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-48496107968009986592018-10-05T22:29:00.001-07:002018-10-05T22:39:20.663-07:00Is Turmeric GOOD or BAD?<div dir="ltr" style="text-align: left;" trbidi="on">
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<i><span style="font-size: 14.0pt; mso-bidi-font-size: 11.0pt;">This new research about turmeric will Surprise you!!<o:p></o:p></span></i></div>
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<a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/bioorganic-and-medicinal-chemistry"><b><span style="font-family: "Times New Roman","serif";">Turmeric</span></b></a><b><span style="font-family: "Times New Roman","serif";"> </span></b><span style="font-family: "Times New Roman","serif";">is a flowering plant of the ginger family, <b><i>Zingiberaceae</i></b>. </span><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/biological-drug-targets"><b><span style="font-family: "Times New Roman","serif";">Curcumin</span></b></a><span style="font-family: "Times New Roman","serif";"> is the active compound that found in turmeric which has effective biological properties. Turmeric has been used in Asia for thousands of years and is a major part of <b>medicine</b>.<o:p></o:p></span></div>
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<span style="font-family: "Times New Roman","serif";">Turmeric might be the foremost effective dietary supplement in presence. <b>Turmeric milk</b> that we were consuming for years have become a new discovery in the West as a. </span><b>“superfood”</b><span style="font-family: "Times New Roman","serif";"><o:p></o:p></span></div>
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<span style="font-family: "Times New Roman","serif";">Medically
speaking, turmeric has traditionally been used to enhance immunity, heal wounds
and improve anti-oxidants in the body. Researches have proven that the right
dosage of turmeric, consumed in any form can assist </span><a href="https://bioorganic-medicinal.chemistryconferences.org/conference-brochure.php"><span style="font-family: "Times New Roman","serif";">Alzheimer's disease</span></a><span style="font-family: "Times New Roman","serif";">, reduce coronary heart attacks
and additionally enhance overall brain function. <o:p></o:p></span></div>
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<span style="font-family: "Times New Roman","serif";">For a
healthy body, specialists and researchers recommend ingesting up to 500 mg of
turmeric each day to hold better health. The dosage also can increase in case
of serious illnesses.<o:p></o:p></span></div>
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<span style="font-family: "Times New Roman","serif";">A
research proves that turmeric has healing properties when used both as a spice
as well as medicine, it may not be really powerful because the body faces a
difficult time ingesting it. If curcumin would not certainly make its way to
the intestine and digestive system, it might as well be <b>good for nothing</b>.<o:p></o:p></span></div>
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<span style="font-family: "Times New Roman","serif";">Curcumin
is the active compound found in turmeric when it enters into the bloodstream
will not be absorbed easily that makes no benefit. Researchers conducted a
study by observing a trail with a group of patients who utilized turmeric to
treat their illness but found zero improvements.<o:p></o:p></span></div>
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<span style="font-family: "Times New Roman","serif";">By
combining turmeric's anti-inflammatory properties with sugary drinks and may be
quite </span><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/pharmaceutical-chemistry"><span style="font-family: "Times New Roman","serif";">toxic and fatal.</span></a><span style="font-family: "Times New Roman","serif";"><o:p></o:p></span></div>
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<span style="font-family: "Times New Roman","serif";">At the
same time, researchers warned against eliminating turmeric from the diet.
Curcumin may not get absorbed easily however it is an effective component with
many uses. Specialists suggest the use of turmeric with <b>black pepper</b> because Black pepper contains a herbal compound which
helps in its absorption. If no longer medicinal, specialist’s support that
turmeric with all its holistic healing benefits would not do the body any kind
of bad.<o:p></o:p></span></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-80150439272344753712018-09-29T04:10:00.003-07:002018-09-29T04:21:16.792-07:00Toxic Blooms<div dir="ltr" style="text-align: left;" trbidi="on">
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<i><span style="font-family: "times new roman" , "serif";">Researchers Reveal Genetic Basis for Toxic Algal Blooms<o:p></o:p></span></i></div>
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<b><span style="background: white; font-family: "times new roman" , serif;"><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/chemical-biology">The algal bloom</a></span></b><span style="background: white; color: #222222; font-family: "times new roman" , "serif";"> is a rapid increase or accumulation in the population of </span><span style="background: white; font-family: "times new roman" , "serif";">algae<span style="color: #222222;"> in freshwater or marine water systems and is recognized by the discolouration in the water from their pigments.<o:p></o:p></span></span></div>
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<span style="background: white; color: #111111; font-family: "times new roman" , "serif";">A </span><a href="https://bioorganic-medicinal.chemistryconferences.org/conference-brochure.php"><b><span style="background: white; font-family: "times new roman" , serif;">Harmful Algal Bloom (HAB)</span></b></a><span style="background: white; color: #111111; font-family: "times new roman" , "serif";"> is an algal bloom that reasons terrible effects to other organisms through the production of natural toxins, mechanical damage to different organisms, or by means of another manner.<o:p></o:p></span></div>
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<span style="color: #04151a; font-family: "times new roman" , "serif";">In humans, the toxin can cause rashes, skin lesions, headaches and stomach pain.<o:p></o:p></span></div>
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<span style="color: #04151a; font-family: "times new roman" , "serif";">Despite decades of research, the trigger that causes algal blooms to begin poisoning their environment has long confounded scientists.<o:p></o:p></span></div>
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<span style="color: #04151a; font-family: "times new roman" , "serif";">Now, researchers have found the genetic underpinning of domoic acid, a harmful neurotoxin. In a new<em>, </em>researchers describe three genes responsible for producing domoic acid in the phytoplankton </span><span style="font-family: "times new roman" , "serif";"><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/computational-chemistryhttps:/bioorganic-medicinal.chemistryconferences.org/abstract-submission.php">Pseudo-nitzschia.</a></span><em><span style="color: #04151a;"><o:p></o:p></span></em></div>
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<span style="color: #04151a; font-family: "times new roman" , "serif";">Monitoring how the clusters of genes behave could one-day yield information on which environmental or biological triggers are responsible for activating them. That information could help fisheries and public health officials predict when harmful algal blooms will occur, allowing them to effectively prepare.<o:p></o:p></span></div>
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<span style="color: #04151a; font-family: "times new roman" , "serif";">The "</span><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/computational-chemistryhttps:/bioorganic-medicinal.chemistryconferences.org/abstract-submission.php"><b><span style="font-family: "times new roman" , serif; text-decoration-line: none;">very small</span></b></a><span style="color: #04151a; font-family: "times new roman" , "serif";">" cluster of genes responsible for the production of the toxin is a relatively rare phenomena compared to other similar organisms, indicating that they may serve some important biological function.<o:p></o:p></span></div>
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<span style="color: #04151a; font-family: "times new roman" , "serif";">Researchers say "It's not there to make us sick. There are different theories for why it's there, including serving as a feeding deterrent,"<o:p></o:p></span></div>
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<span style="color: #04151a; font-family: "times new roman" , "serif";">They speculate the toxin may deter organisms that would feed upon the algae. Or it may be that the toxin allows algae to chemically bond to nutrients, such as iron, present in the water.<o:p></o:p></span></div>
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<b><i><span style="color: #04151a; font-family: "times new roman" , "serif";">The discovery of these genes will allow us to explore many theories</span></i></b><span style="color: #04151a; font-family: "times new roman" , "serif";"><o:p></o:p></span></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-82814196074674456092018-09-24T04:32:00.002-07:002018-09-24T04:32:40.477-07:00Shaping the Future: <div dir="ltr" style="text-align: left;" trbidi="on">
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<i>Computational Exploration and Design of Functional Compounds<o:p></o:p></i></div>
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Researchers work on the development of forefront <b>computational methods</b> at the interface of <b>chemistry, biology, physics</b> and <b>materials science</b>. Highly accurate approaches derived from quantum mechanics have been the focus of their research, as have applications of their methods which include a broad range of systems – from <a href="https://bioorganic-medicinal.chemistryconferences.org/conference-brochure.php"><b>(bio-) molecules</b></a><b> </b>over functional co-ordination compounds, to condensed phase systems. In-depth study and informed <b><i>in silico</i></b><i> design</i> are carried out to obtain systems with desired properties and functionalities. Examples include complex processes such as solar light-driven catalysis for sustainable hydrogen production as a promising solution to the world’s energy problem.<o:p></o:p></div>
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<a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/computational-chemistry"><span style="font-family: "Calibri","sans-serif"; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin;">Theoretical and computational chemistry, biophysics, and materials science</span></a><span style="color: #1f497d; font-family: "Calibri","sans-serif"; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-themecolor: text2;"> <o:p></o:p></span></h2>
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<a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/drug-delivery-techniques"><b>Investigation of chiral systems</b></a><b><o:p></o:p></b></div>
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<b>Chirality</b> plays a vital role in many aspects of chemistry, biology, and physics. Vibrational Raman optical activity spectroscopy enables valuable information on the structure and dynamics of systems and has been widely used to study molecules in solution. Based on a newly developed approach, it became possible to present the first spectra for chiral metal complexes and a large <b>metalloprotein</b>, thus opening up an exciting field of research for coordination compounds as well as the theoretical exploration of complex (bio-)molecules. The special case of Resonance Raman optical activity has also been further developed, which can provide important additional information due to resonance with electronically excited state(s).<o:p></o:p></div>
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Alongside static computational approaches, the group has presented a method for the first calculation of vibrational Raman optical activity spectra via forefront ab initio molecular dynamics, which includes effects such as anharmonicity and can treat systems at ambient environment.<o:p></o:p></div>
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<a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/global-chemical-analysis"><b>Analysis of functional compounds</b></a><b><o:p></o:p></b></div>
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Having been involved in the study of various compounds ranging from (bio-)molecules over liquids to molecules on surfaces, recent group projects in collaboration with other groups have also, for example, concerned the investigation of electronic communication in dirhenium complexes, photoinduced proton-coupled electron transfer, and the development of refinement procedures for improved agreement of computational models and experimental data.<o:p></o:p></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-24089127813831551202018-09-15T04:03:00.000-07:002018-09-15T04:05:10.970-07:00Join Your Hands for a Good Cause<div dir="ltr" style="text-align: left;" trbidi="on">
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<b><a href="https://bioorganic-medicinal.chemistryconferences.org/">World Congress on Bioorganic and Medicinal Chemistry</a></b> scheduled on November 12-13, 2018 Dubai, UAE goes with the theme <i>Explore the latest trends in Bioorganic and Medicinal Chemistry</i>.<o:p></o:p></div>
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<b><a href="https://d2cax41o7ahm5l.cloudfront.net/cs/pdfs/bioorganic-medicinal-2018-who-attends.pdf">Why Attend?</a></b><o:p></o:p></div>
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<em><span style="background: white; font-family: "calibri" , "sans-serif";"><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/bio-organic-and-medicinal-chemistry"><span style="color: windowtext; text-decoration-line: none;">Bioorganic Medicinal 2018</span></a></span></em><span style="background: white;"><span style="box-sizing: border-box;"> </span> is an international event focusing on the core knowledge and major advances in the ever-expanding field of Bioorganic and Medicinal Chemistry by attracting experts on a global scale. It is a global platform to discuss the innovative researches and developments in the Bioorganic and Medicinal Chemistry. It will be a golden opportunity to meet eminent personalities and to learn the latest technological advancements.<o:p></o:p></span></div>
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<b>The distinctive features of the conference includes<o:p></o:p></b></div>
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<!--[if !supportLists]--><span lang="EN-US" style="font-family: "symbol"; mso-ansi-language: EN-US; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;">·<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;"> </span></span><!--[endif]--><span lang="EN-US">Structural & Medicinal Biochemistry<o:p></o:p></span></div>
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<!--[if !supportLists]--><span lang="EN-US" style="font-family: "symbol"; mso-ansi-language: EN-US; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;">·<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;"> </span></span><!--[endif]--><span lang="EN-US">Biological Drug Targets<o:p></o:p></span></div>
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<!--[if !supportLists]--><span lang="EN-US" style="font-family: "symbol"; mso-ansi-language: EN-US; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;">·<span style="font-family: "times new roman"; font-size: 7pt; font-stretch: normal; line-height: normal;"> </span></span><!--[endif]--><span lang="EN-US">Drug delivery Techniques<o:p></o:p></span></div>
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<b><u><a href="https://bioorganic-medicinal.chemistryconferences.org/organizing-committee.php">Our Honourable Organizing Committee:</a><o:p></o:p></u></b></div>
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<o:p><br /><a href="https://bioorganic-medicinal.chemistryconferences.org/conference-brochure.php"> </a></o:p><b><u><a href="https://bioorganic-medicinal.chemistryconferences.org/conference-brochure.php">Our Guest of Honor:</a></u></b></div>
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<span style="background: white; font-family: "segoe ui" , "sans-serif"; font-size: 10.5pt; line-height: 115%;">We are privileged to have</span> <b>Dr.Anthony Melvin Crasto</b> as our honourable guest.<o:p></o:p></div>
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<b><u><a href="https://bioorganic-medicinal.chemistryconferences.org/renowned-speakers.php">Our Renowned Speakers</a></u></b></div>
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<b><a href="https://bioorganic-medicinal.chemistryconferences.org/abstract-submission.php">Poster Presentations:<o:p></o:p></a></b></div>
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For all the speaker’s details visit our <a href="https://bioorganic-medicinal.chemistryconferences.org/scientific-program">Scientific Program</a><o:p></o:p></div>
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If you want to be a part of our international summit contact<o:p></o:p></div>
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Claira Williams @ <a href="mailto:medicinalchemistry@memeetings.net">medicinalchemistry@memeetings.net</a><o:p></o:p></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-68410615384978815402018-09-13T23:48:00.002-07:002018-09-13T23:48:38.219-07:00A Historic FLUORINE Discovery<div dir="ltr" style="text-align: left;" trbidi="on">
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<b><span style="background: #F5F6F5; color: #222222; mso-bidi-font-family: Arial;">Fluorine</span></b><span style="background: #F5F6F5; color: #222222; mso-bidi-font-family: Arial;"> is one of
the foremost crucial components of life. In its fluoride form, it is a mineral
with anti-acid properties utilized in toothpaste and drinking water to prevent
dental cavities. This small, non-toxic element is also broadly utilized by </span><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/bioorganic-and-medicinal-chemistry"><span style="background: #F5F6F5; mso-bidi-font-family: Arial;">medicinal chemists</span></a><span style="background: #F5F6F5; color: #222222; mso-bidi-font-family: Arial;"> in cancer
treatment, antibiotics, anti-depressants, steroids and different drugs.
Fluorine is regular in modern drugs as it stabilizes drugs and improves their
biological activity.</span><span style="color: #222222; mso-bidi-font-family: Arial;"><br />
<span style="background: #F5F6F5;">For many years, researchers have been studying
the regulation of <b>thiols</b>, compounds
that affect a variety of biological functions in mammals including redox stress
levels, energy balance, cellular signalling, coronary heart health, and
autoimmune and neurological conditions. While thiol levels are stable, people
are normally healthy. Once they increase too much and for too lengthy,
situations including rheumatoid arthritis, breast cancer, Alzheimer's and
Parkinson's diseases can develop.</span><br />
</span><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/medicinal-chemistry"><span style="background: #F5F6F5; mso-bidi-font-family: Arial;">Cysteine dioxygenase
(CDO)</span></a><span style="background: #F5F6F5; color: #222222; mso-bidi-font-family: Arial;"> and </span><a href="https://bioorganic-medicinal.chemistryconferences.org/conference-brochure.php"><span style="background: #F5F6F5; mso-bidi-font-family: Arial;">cysteamine dioxygenase
(ADO</span></a><span style="background: #F5F6F5; color: #222222; mso-bidi-font-family: Arial;">) regulates the thiol levels in our body. While the thiol
levels are increased, CDO and ADO develop catalytic amplifiers to quickly
eliminate thiol from the body. Scientists don't yet understand exactly how the
enzymes make the amplifiers.<o:p></o:p></span></div>
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<span style="background: #F5F6F5; color: #222222; mso-bidi-font-family: Arial;">The scientists carried out a method on CDO known as <b>genetic code expansion</b>.</span><span style="color: #222222; mso-bidi-font-family: Arial;"><br />
<span style="background: #F5F6F5;">The researchers made a new form of CDO with
two exceptionally strong carbon-fluorine bonds. This need to have made it tougher
for the enzyme to break those carbon-fluorine bonds and bring its catalytic
amplifier. What they found, however, surprised them. They observed that the
modified CDO was still capable to break its carbon-fluorine bonds to generate
its full catalytic assembly.</span><br />
<span style="background: #F5F6F5;">This is the first time that scientists have
confirmed the cleavage (breakage) of a carbon-fluorine bond thru oxidation in
proteins. Because of this, it may be possible that human bodies are able to
break these bonds in the drugs that are consumed.</span><br />
<span style="background: #F5F6F5;">Researcher’s additionally uncovered clues as
to how thiols generate their catalytic amplifiers after the proteins are built.</span><br />
<span style="background: #F5F6F5;">More than 20% of </span></span><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/pharmaceutical-chemistry"><span style="background: #F5F6F5; mso-bidi-font-family: Arial;">pharmaceutical drugs</span></a><span style="background: #F5F6F5; color: #222222; mso-bidi-font-family: Arial;"> contain
fluorine. Due to their energy, fluorine-carbon bonds resist normal drug
metabolism and may extend the useful lifetime of the drug in the body. Fluorine
in drug molecules can also increase their capability to cross membrane barriers
and enter cells. That the carbon-fluorine is strongly safe to cleavage could be
a long-held conviction in medicinal chemistry.</span><span style="color: #222222; mso-bidi-font-family: Arial;"><br />
<span style="background: #F5F6F5;">Pharmaceutical companies have to remind that
fluorine chemistry is very complex. Even though valuable, it is highly
recommended to proceed with caution, because there's still a lot to learn.</span><br />
<span style="background: #F5F6F5;">Understanding the C-F bond is important to our
understanding of </span></span><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/drug-design-discovery-and-development"><span style="background: #F5F6F5; mso-bidi-font-family: Arial;">drug design</span></a><span style="background: #F5F6F5; color: #222222; mso-bidi-font-family: Arial;"> and
enhancing the lives of patients.</span><o:p></o:p></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-4259819394908887292018-09-03T02:11:00.001-07:002018-09-03T02:12:23.253-07:00ENZYMES: Key for Drug Development<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="background: white; font-size: 12pt; line-height: 115%;">Researchers are mapping the characteristic of particular enzymes which may also facilitate the </span><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/drug-design-discovery-and-development"><span style="background: white; font-size: 12.0pt; line-height: 115%; mso-bidi-font-family: Arial;">development of new drugs</span></a><span style="background: white; font-size: 12pt; line-height: 115%;"> to combat bacterial contamination, cancer and probably neurodegenerative diseases like autism, Down syndrome, Parkinson's disease and Alzheimer's. <o:p></o:p></span></div>
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<b><span style="background: white; font-size: 12pt; line-height: 115%;">Sulfur</span></b><span style="background: white; font-size: 12pt; line-height: 115%;"> is one of most abundant elements in the body however little is thought approximately the enzymes concerned in its metabolism<o:p></o:p></span></div>
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<b><span style="background: white; font-size: 12pt; line-height: 115%;">Autistic, Alzheimer</span></b><span style="background: white; font-size: 12pt; line-height: 115%;"> and <b>Down syndrome</b> patients all reveal abnormal sulfur metabolism. If we will work out how human sulfur-oxidizing enzymes function, or more crucially, how their behaviour changes in bacteria or in specific diseases, this information may be used for the rational design of drugs targeted for those diseases. Presently, no such technology exists.<o:p></o:p></span></div>
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<span style="background: white; font-size: 12pt; line-height: 115%;">By means of comparing the behaviour of these enzymes in human beings to bacteria, we also can open up possibilities to stamp out "</span><a href="https://bioorganic-medicinal.chemistryconferences.org/conference-brochure.php"><b><span style="background: white; font-size: 12.0pt; line-height: 115%; mso-bidi-font-family: Arial;">superbugs</span></b></a><span style="background: white; font-size: 12pt; line-height: 115%;">" via offering an alternate method to disrupt bacterial metabolism without adversely affecting the patient,</span><span style="background-color: white; font-size: 12pt;"> That is specifically important as we are now seeing widespread drug-resistant bacterial strains</span></div>
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<span style="background: white; font-size: 12pt; line-height: 115%;">Researchers use rapid-mix, freeze-quench techniques to </span><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/structural-molecular-biochemistry"><b><span style="background: white; font-size: 12.0pt; line-height: 115%; mso-bidi-font-family: Arial;">'trap'</span></b></a><b><span style="background: white; font-size: 12pt; line-height: 115%;"> </span></b><span style="background: white; font-size: 12pt; line-height: 115%;">and monitor the progress of chemical reactions at millisecond intervals. Analysis of those consequences offers a step-by-step picture of how these enzymes function in both mammals and bacteria. <o:p></o:p></span></div>
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<span style="background: white; font-size: 12pt; line-height: 115%;">They look at fundamental life processes outside the traditional sphere of biochemistry and employs very current strategies to analyze enzyme function and regulation</span></div>
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<span style="background: white; font-size: 12pt; line-height: 115%;">By providing the fundamental scientific background had to develop treatments for important conditions and they want to make a real impact on the development of new scientific solutions</span><span style="font-size: 12.0pt; line-height: 115%;"><o:p></o:p></span></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-84737626988539939742018-08-19T22:10:00.000-07:002018-08-19T22:10:43.740-07:00A Novel Drug for Liver Cancer<div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="https://bioorganic-medicinal.chemistryconferences.org/conference-brochure.php"><b><span style="background: white; mso-bidi-font-family: Arial;">Hepatocellular carcinoma (HCC)</span></b></a><span style="background: white;"> accounts for more than 90% of all liver cancers. Due to its restricted treatment options and poor diagnosis, there may be presently an unmet need for alternative, greater effective treatments. In a new study, researchers have developed a unique peptide drug known as FFW that might probably reduce tumor growth and gradual development of cancer.<o:p></o:p></span></div>
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<span style="background: white;">Previous research has examined SALL4, a protein related to tumor growth, as a prognosis marker and drug target for HCC, in addition to other cancers. However, it's been previously categorized as an “<b><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/biological-drug-targets">undruggable target</a></b>,” according to the researchers.<o:p></o:p></span></div>
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<span style="background: white;">In prior studies, they observed that the SALL4 protein works with another protein, NuRD, to make an association typically imperative for the enhancement of cancers counting HCC. Drug molecules that act on protein interactions which incorporate SALL4-NuRD frequently require the target proteins to have a small “</span><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/pharmaceutical-chemistry"><b><span style="background: white; mso-bidi-font-family: Arial;">pocket</span></b></a><span style="background: white;">” in their 3-d structure in which the drug molecule can reside and take effect.<o:p></o:p></span></div>
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<span style="background: white;">Rather than trying to find ‘pockets’ on SALL4, the research group designed a bio-molecule to block the interaction between SALL4 and NuRD. In lab experiments, blocking the interaction has brought about tumor cell death and decreased movement of tumor cells.<o:p></o:p></span></div>
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<span style="background: white;">This bio-molecule, peptide FWW, is a small chain of amino acids which can interfere with these interactions and efficiently block the large protein-protein interaction surface, without needing a “pocket” to take effect. Moreover, the researchers observed that FWW should reduce the growth of </span><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/medicinal-biochemistry"><span style="background: white; mso-bidi-font-family: Arial;">Sorafenib-resistant HCC</span></a><span style="background: white;">, while utilized in combination with Sorafenib. <o:p></o:p></span></div>
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<span style="background: white;">Focusing on the SALL4-NuRD interaction need to have vital
implications for the treatment of HCC, this can translate to a broader range of
cancers with accelerated SALL4. In the latest work, the research team has
additionally demonstrated a powerful approach to appropriately target oncogenes
formerly considered undruggable. <o:p></o:p></span></div>
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<span style="background: white;">“<i>Moving forward,
researchers hope to analyze how the targeting of these protein interactions may
pan out in different cancer types</i>.”<o:p></o:p></span></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com1tag:blogger.com,1999:blog-1418356858135207183.post-4008467439250268812018-08-13T01:57:00.001-07:002018-08-13T01:58:43.670-07:00Alcoholism and Addiction<div dir="ltr" style="text-align: left;" trbidi="on">
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<i><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; mso-fareast-language: EN-IN;"><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/drug-design-discovery-and-development">A drug that decreases alcohol's effects on the brain</a></span></i><i><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; mso-fareast-language: EN-IN;"><o:p></o:p></span></i></div>
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Alcohol use disorders may have devastating effects on a person's health, relationships, and finances. But for some, the feeling they get when taking a drink temporarily outweighs those other issues. Researchers have built up a novel medication that declines alcohol's effects on "<a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/structural-molecular-biochemistry"><b>reward system</b>,</a>" causing rats to self-administer the beverage less frequently.</div>
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<o:p></o:p>Once devoured, the
liquor goes into the brain and associated with the neurotransmitters and their
receptors incorporating some worried in reward-system pathways. When activated,
these pathways can cause emotions of pleasure, relaxation, and craving. Even
though alcohol-treatment pills that interfere with the reward system exist,
these pills aren't very powerful and may have extreme aspect results. For
effective treatment, researchers concentrated their efforts on a protein
receptor known as <a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/pharmaceutical-chemistry">GPR88</a> which is found dominatingly in reward-associated regions of the brain. Previous
studies on genetically modified mice which lack GPR88 protein showed that these
animals seek and consume alcohol more than normal mice. This led the researchers
to surprise if a drug that stimulates GPR88 ought to reduce alcohol cravings.
They had formerly developed a synthetic small molecule that activates GPR88 in
vitro; however, this molecule couldn't effectively pass the blood-brain
barrier.</div>
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The researchers
tweaked the structure of the compound to make it more likely to go into the
brain. They arrived at a molecule called <a href="https://bioorganic-medicinal.chemistryconferences.org/conference-brochure.php">RTI-13951-33</a> that become effective, selective for GPR88
and will pass the blood-brain barrier. Whilst given RTI-13951-33,
non-engineered rats drank less alcohol than earlier than they received the
drug. In comparison, the rats gave themselves sugar water on the equal
frequency with or without the drug. The researchers are now analyzing the
molecule in both wild-type mice and those that lack the GPR88 receptor to show
that the drug is specific for that receptor.<o:p></o:p></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-89462508256265467552018-08-06T01:07:00.000-07:002018-08-06T01:08:19.955-07:00A New Drug Puts Cancer Cells Permanently to 'SLEEP'<div dir="ltr" style="text-align: left;" trbidi="on">
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<i><span style="background: white; color: #1f497d; font-family: "cambria" , "serif"; font-size: 10.0pt;">Scientist discovered anti-cancer drug without the usual side effects of conventional cancer treatments.<o:p></o:p></span></i></div>
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<span style="background: white; color: #111111; font-size: 12.0pt; line-height: 115%;">Research up to now has proven progress in delaying cancer relapse in addition to treating some forms of cancer.<o:p></o:p></span></div>
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<span style="background: white; color: #111111; font-size: 12.0pt; line-height: 115%;">The technique of preventing the growth of tumors occurs without damaging any cell's DNA, which takes place in </span><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/medicinal-chemistry"><span style="background: white; font-size: 12.0pt; line-height: 115%;">traditional treatments</span></a><span style="background: white; color: #111111; font-size: 12.0pt; line-height: 115%;"> including chemotherapy and radiotherapy. <o:p></o:p></span></div>
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<a href="https://bioorganic-medicinal.chemistryconferences.org/conference-brochure.php"><span style="background: white; font-size: 12.0pt; line-height: 115%;">The future of cancer</span></a><span style="background: white; color: #111111; font-size: 12.0pt; line-height: 115%;"> therapy might be is to have directed and focused treatments so as to work on specific patient groups. A new kind of approach to cancer therapy that is preventing cancer cells from growing, however, leaving the normal cells especially unaffected and that's by harnessing the body's normal defenses against unrestricted growth.<o:p></o:p></span></div>
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<span style="background: white; color: #111111; font-size: 12.0pt; line-height: 115%;">The development of the drug is at a pre-clinical stage. The research indicates that by targeting certain proteins recognized to play the primary function in the development of cancer, doctors can essentially prevent the disease.<o:p></o:p></span></div>
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<span style="background: white; color: #111111; font-size: 12.0pt; line-height: 115%;">These proteins are known as </span><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/pharmaceutical-chemistry"><span style="background: white; font-size: 12.0pt; line-height: 115%;">KAT6A</span></a><span style="background: white; color: #111111; font-size: 12.0pt; line-height: 115%;"> and </span><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/bioorganic-and-medicinal-chemistry"><span style="background: white; font-size: 12.0pt; line-height: 115%;">KAT6B</span></a><span style="background: white; color: #111111; font-size: 12.0pt; line-height: 115%;"> and they're proteins that affect certain genes most commonly observed in cancers. The disease-causing protein that has been targeted has actually not been able to be targeted before with a small-molecule potential drug. Researchers developed a small molecule that inhibits these proteins. <o:p></o:p></span></div>
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<span style="background: white; color: #111111; font-size: 12.0pt; line-height: 115%;">The way that those epigenetic drugs work especially this drug is that it freezes the cell, however, does not kill it off. In case you are at a late stage disease and have lots of tumors in your body, we obviously need to get rid of that first before seeking to prevent the cells from growing. This drug could be definitely beneficial after the usage of initial therapy that gets rid of the original tumor mass and we might use that new type of epigenetic drug to prevent any tumors from developing back, that's a truly beneficial concept and idea.</span><span style="font-size: 12.0pt; line-height: 115%;"><o:p></o:p></span></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-12923667715967029172018-07-30T02:05:00.004-07:002018-08-03T22:00:37.036-07:00Artificial Intelligence Seeks Out New Drugs<div dir="ltr" style="text-align: left;" trbidi="on">
<i><span style="color: #1f497d; font-family: "calibri" , "sans-serif"; font-size: 11.0pt; line-height: 115%;">How drug candidates interact with their target to treat disease is the key to drug development?</span></i><br />
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<span style="font-size: 12.0pt; line-height: 115%; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-IN;">Machine learning can go way beyond more classical molecular docking. The new artificial intelligence tool does not depend on the structure of proteins so it can be applied in cases where </span><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/structural-molecular-biochemistry"><span style="font-size: 12.0pt; line-height: 115%; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-IN;">molecular docking</span></a><span style="font-size: 12.0pt; line-height: 115%; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-IN;"> might not. This tool is also quicker, hence cheaper. ‘Docking tends to be computationally expensive, whereas we can profile one molecule against thousands of drug targets in less than 10 minutes.<o:p></o:p></span></div>
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<span style="font-size: 12.0pt; line-height: 115%; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-IN;">Researchers relied on a huge database of compounds and drug targets they used to ‘teach’ a single desktop computer. They used two different machine learning methods: ‘One gives a bind/don’t bind answer … and the other use several decision trees to predict an affinity value. Then, the algorithm gives a prediction. In this case, it suggested likely targets for the natural product β-lapachone – among them enzyme 5-lipoxygenase. Machine learning allows us to leverage statistical patterns found in data. When high-quality datasets exist, machine learning can model these phenomena much faster and cheaper … accelerating efforts for the discovery of novel drugs.<o:p></o:p></span></div>
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<span style="font-size: 12.0pt; line-height: 115%; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-IN;">The team’s chemists also synthesized a set of eight β-lapachone analogues, and tested their binding affinity to 5-lipoxygenase. None of them outperformed β-lapachone anticancer activity, however. The algorithm had found a perfect match. This highlights the importance of the structure and substitution pattern for bioactivity. To further analyze how β-lapachone binds to its target enzyme, they created enzyme models and carried out computational studies that confirmed what they had found in the lab – β-lapachone binds strongly to the enzyme’s active site.<o:p></o:p></span></div>
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<span style="font-size: 12.0pt; line-height: 115%; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-IN;">In future artificial intelligence will become essential in the search for, and development of, new ligands and drug candidates. Chemistry labs will almost certainly change thanks to these </span><a href="https://bioorganic-medicinal.chemistryconferences.org/conference-brochure.php"><span style="font-size: 12.0pt; line-height: 115%; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-IN;">new techniques</span></a><span style="font-size: 12.0pt; line-height: 115%; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-IN;">. Artificial intelligence will be integrated into all aspects: simulation, experimental planning, and characterization. <o:p></o:p></span></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-52044010692033700752018-07-13T02:18:00.001-07:002018-07-13T02:18:08.238-07:00A New Way For Producing Medical Therapeutic Proteins<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="background: white; color: #333333; mso-bidi-font-family: Arial;"><span style="font-family: Georgia, Times New Roman, serif;">Bacterial systems are some of the simplest and most effective platforms for the expression of recombinant proteins. They are more cost-effective compared to other methods. However, in addition to the target recombinant proteins, cells also produce a large number of endogenous proteins, including SlyD. It is a small protein consisting of 3 domains. Its C-terminal region is rich in histidine residues, therefore SlyD exhibits a high affinity for the 2-valent ions and is purified together with the target proteins in the course of metal-affinity chromatography. This results in the need for additional purification steps and, as a consequence, increases the cost of the technological process for obtaining therapeutic recombinant proteins.</span></span><o:p></o:p></div>
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<span style="color: #333333;"><span style="font-family: Georgia, Times New Roman, serif;">Researchers have obtained a series of <em style="box-sizing: border-box;">E. coli</em>strains deficient in the SlyD/SlyX genes. The strains were engineered using λ-red mediated chromosomal deletion.<o:p></o:p></span></span></div>
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<span style="color: #333333;"><span style="font-family: Georgia, Times New Roman, serif;">The sequence of SlyD/SlyX in the <em style="box-sizing: border-box;">E. coli</em> genome was replaced by a gene responsible for resistance to the antibiotic kanamycin that was flanked on both sides by FRT sites, from where it was later removed by FLP recombinase.<o:p></o:p></span></span></div>
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<span style="color: #333333;"><span style="font-family: Georgia, Times New Roman, serif;">Using the example of recombinant bispecific protein MYSTI-2 consisting of two different modules, which are active centers of antibodies against mouse proteins F4/80 and TNF, the scientists compared the activity of proteins isolated from the original and mutant strains. As a result of the study, it was determined that the removal from the <em style="box-sizing: border-box;">E. coli</em>genome of the SlyD and SlyX genes, which presumably encode chaperones that support the spatial structure of Escherichia coli proteins, does not result in a disruption of recombinant proteins' functional activity.</span><span style="font-family: Calibri, sans-serif; font-size: 11pt;"><o:p></o:p></span></span></div>
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<span style="color: #333333;"><span style="font-family: Georgia, Times New Roman, serif;">By obtaining original <em style="box-sizing: border-box;">E. coli</em> strains, the researchers were able to solve the problem of contamination of recombinant proteins and to ensure their successful single-stage purification by metal-affinity chromatography.<o:p></o:p></span></span></div>
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<span style="color: #333333;"><span style="font-family: Georgia, Times New Roman, serif;">The obtained set of slyD/slyX-deficient strains of <em style="box-sizing: border-box;">E. coli</em> can be used to produce in a pure form a wide range of prokaryotic and eukaryotic proteins, including medical therapeutic proteins. This makes the development and production of new medicinal and preventive biological preparations easier, simpler and cheaper.</span><span style="font-family: Calibri, sans-serif; font-size: 11pt;"><o:p></o:p></span></span></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-26623781716954746102018-07-06T02:28:00.001-07:002018-07-06T02:32:29.915-07:00What will be the Future of Existing Drugs..??<div dir="ltr" style="text-align: left;" trbidi="on">
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<i><span style="background: white;"><span style="color: #0b5394;">Combining drugs and the future</span></span></i></div>
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<b><span style="background: white;">Drug combinations alter the effectiveness of
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<span style="background: white; mso-bidi-font-family: Arial;">The
efficiency of antibiotics might be altered by combining them with each other,
non-antibiotic drugs or else even with food additives. Depending on the
bacterial species, a few combinations stop antibiotics from functioning to
their complete capacity as others begin to overcome antibiotic resistance.<o:p></o:p></span></div>
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<b><span style="background: white; mso-bidi-font-family: Arial;">Succeeding antibiotic
resistance<o:p></o:p></span></b></div>
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<span style="background: white; mso-bidi-font-family: Arial;">Overuse
and misuse of antibiotics have led to significant antibiotic resistance. Particular
combinations of drugs can assist in preventing multi-drug resistant bacterial infections;
however, they may be largely unexplored and infrequently utilized in clinics<o:p></o:p></span></div>
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<span style="background: white; mso-bidi-font-family: Arial;">Though
most of the examined drug combinations reduced the antibiotics’ effect, there
were over 500 drug combinations which improved the antibiotic effect. These
positive pairings also examined in multi-drug resistant bacteria, they have
been found to improve antibiotic effects.<o:p></o:p></span></div>
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<span style="background: white; mso-bidi-font-family: Arial;">When
vanillin - the compound that gives vanilla its exclusive taste - became paired
with one specific antibiotic called spectinomycin, it helped the antibiotic to
enter bacterial cells and inhibit their growth. Spectinomycin is rarely used
these days because of the bacterial resistance that was developed against it.<o:p></o:p></span></div>
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<b><span style="background: white; mso-bidi-font-family: Arial;">Pairings this may increase
the arsenal of weapons in the war against antibiotic resistance.<o:p></o:p></span></b></div>
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<span style="background: white; mso-bidi-font-family: Arial;">However,
vanillin lessened the effect of many different kinds of antibiotics. Vanillin
works in a similar manner to aspirin to reduce many antibiotic actions - even
though its results in human cells have not been examined, they’re most likely
different.<o:p></o:p></span></div>
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<span style="background: white; mso-bidi-font-family: Arial;">According
to researchers, combinations of drugs that lower the effect of antibiotics may
also be beneficial to human health. Antibiotics can cause collateral damage and
side effects because they target healthy bacteria as well. However, the effects
of these drug combinations are particularly selective, and often only affect
some bacterial species. In the future, we might utilize drug combinations to
specifically stop the harmful impacts of antibiotics on healthy bacteria. This
will also decrease antibiotic resistance development, as healthy bacteria might
not be sited under pressure to develop antibiotic resistance that might
afterward be transferred to harmful bacteria.<o:p></o:p></span></div>
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<b>For more details
visit</b>: <a href="https://bioorganic-medicinal.chemistryconferences.org/">https://bioorganic-medicinal.chemistryconferences.org</a><o:p></o:p></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-81734074159738355302018-06-29T05:09:00.003-07:002018-07-06T02:33:08.163-07:00Can We Use NANOTECHNOLOGY to Transform Our Own Immune Cells into CANCER Serial Killers?<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="font-family: "times new roman" , serif;">Researchers have proven the development of techniques that activate immune cells, specifically T-cells, to track down and eradicate tumor cells.<o:p></o:p></span></div>
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<span style="font-family: "times new roman" , serif; letter-spacing: 0.35pt;">They developed a technique for rapidly functionalizing T-cell surfaces without the need for genetic engineering. The study demonstrated the capability to safely eliminate solid tumors in mice. Furthermore, the studies exhibited effectiveness against breast cancer, the most common form of cancer among women.<o:p></o:p></span></div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh12kNriaLIqfN7BT-se1zQVjAaDgY2_-ZzJfNWfBnbdAkdL86Pv4MTPeW2k9zD5zaDYvfSnN4BwaEOo_JCBiokBvbo3HGlFzJsp0jyCFhUSYClhzAYAjZjqKtlBoMDqJeOazYEnXeRJkY/s1600/sg_0IQNmimwlN.jpg" imageanchor="1" style="color: #00a1a4; margin-left: 1em; margin-right: 1em; text-decoration-line: none;"><img border="0" data-original-height="540" data-original-width="960" height="225" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh12kNriaLIqfN7BT-se1zQVjAaDgY2_-ZzJfNWfBnbdAkdL86Pv4MTPeW2k9zD5zaDYvfSnN4BwaEOo_JCBiokBvbo3HGlFzJsp0jyCFhUSYClhzAYAjZjqKtlBoMDqJeOazYEnXeRJkY/s400/sg_0IQNmimwlN.jpg" style="border: none; position: relative;" width="400" /></a></div>
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<span style="font-family: "times new roman" , serif; letter-spacing: 0.35pt;">Researchers designed protein-based nanorings that bind to T-cells. The modified T-cells — known as Prosthetic Antigen Receptors (PAR-T) — quickly and continuously destroy cancer cells upon finding them.<o:p></o:p></span></div>
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<span style="font-family: "times new roman" , serif; letter-spacing: 0.35pt;">The researchers have proven that they can use the Food and Drug Administration (FDA) approved drug Trimethoprim to exchange the nanorings off to assist address potential toxic side effects that may arise with immune cell-based anticancer treatments.<o:p></o:p></span></div>
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<span style="font-family: "times new roman" , serif; letter-spacing: 0.35pt;">With some success, using the tools of chemical biology and nanotechnology, they'll be able to increase the scope of cancer immunotherapy for the treatment of a number of the toughest cancers we are facing<o:p></o:p></span></div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhDnlFUS12E0AvZ94yDZYv6E_bzHGhaTNDgTbKgNmpYp_xif-9kh5Ic_UCUPUfdBt-GV_02H57EYnPW_Saat3330kQFeDFmGdRoWshm0740q7QFkUUSyXPrup1N_VJpV1bIe_qKWcOWrlc/s1600/killing_cancer_cells_by_jerrykongart-d325hkr.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="645" data-original-width="900" height="286" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhDnlFUS12E0AvZ94yDZYv6E_bzHGhaTNDgTbKgNmpYp_xif-9kh5Ic_UCUPUfdBt-GV_02H57EYnPW_Saat3330kQFeDFmGdRoWshm0740q7QFkUUSyXPrup1N_VJpV1bIe_qKWcOWrlc/s400/killing_cancer_cells_by_jerrykongart-d325hkr.jpg" width="400" /></a></div>
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<span style="font-family: "times new roman" , serif; letter-spacing: 0.35pt;">Researchers are currently working on targeting cancer stem cells, which is key to preventing cancer from recurring. Initial research has shown that a PAR-T cell approach can work in this area, too.</span><br />
<span style="font-family: "times new roman" , serif; letter-spacing: 0.35pt;"><br /></span>
<span style="font-family: "times new roman" , serif; letter-spacing: 0.35pt;">Visit:<a href="http://bioorganic-medicinal.chemistryconferences.org/"> http://bioorganic-medicinal.chemistryconferences.org</a></span></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-50279841533732456472018-06-24T23:44:00.001-07:002018-06-24T23:45:28.078-07:00Application of Flow Chemistry in Medicinal Chemistry Programmes<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="color: #333333;">The <b><a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/pharmaceutical-chemistry">Pharmaceutical Sciences</a></b> department focuses mainly on the discovery and characterization of
synthetic and natural bioactive compounds, and the improvement of
pharmaceutical formulations to enhance the pharmacokinetics and
pharmacodynamics of lead compounds.<o:p></o:p></span></div>
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<span style="color: #333333;"><br /></span></div>
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<span style="color: #333333;">Only a few laboratories
are especially interested in steroid chemistry and receptors and have
experience in the implementation of enabling technology – including <b>flow
chemistry</b> – to assist complicated syntheses, generation of lead-like compound
libraries and large-scale compound preparation.<o:p></o:p></span></div>
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<span style="color: #333333;">One of the most vital
features of the modular Asia system to diversify our flow equipment is the
extraordinarily smooth and precise flow achieved by using the Asia pump, even
at the low flow rates we use in our approaches. it is also definitely
beneficial for compound library generation, screening reactions and
optimization research, as it is easy to work with small quantities of the
compound, that is crucial when you work with expensive substances, including
enzymes.<o:p></o:p></span></div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjUEOQjDdSVYakTg6N0qOQplTPfHgsu4xUNHmy-61Mu_7wMJsIxFmSyPSlsLTsXYdRYMpJ8ONsNOBMy__rN7lKD4a-5clbojfFdNYfJuNnpUcvjtvofzlKrYJFAM6RZhc6tLQR1iy32ncQ/s1600/shutterstock_112027526.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="933" data-original-width="1400" height="266" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjUEOQjDdSVYakTg6N0qOQplTPfHgsu4xUNHmy-61Mu_7wMJsIxFmSyPSlsLTsXYdRYMpJ8ONsNOBMy__rN7lKD4a-5clbojfFdNYfJuNnpUcvjtvofzlKrYJFAM6RZhc6tLQR1iy32ncQ/s400/shutterstock_112027526.jpg" width="400" /></a></div>
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<span style="color: #333333;">Researchers are very pleased with the Asia system; it is every bit as excellent as they predicted and wonderful to be able to translate biosynthetic steroid pathways into continuous flow processes to expedite <b>early drug discovery</b>.</span></div>
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<span style="color: #333333;">For more details visit: <a href="https://bioorganic-medicinal.chemistryconferences.org/">https://bioorganic-medicinal.chemistryconferences.org</a><o:p></o:p></span></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-81111973557022243582018-06-19T20:21:00.003-07:002018-06-19T20:21:41.145-07:00New Gene associated with Parkinson’s disease <div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="font-size: 12.0pt; line-height: 115%;">Dopamine is a major neurotransmitter in the brain. A dopamine
deficiency is associated with Parkinson's disease, while overactive dopaminergic
systems are associated with schizophrenia and other mental diseases. </span>Recent
research associated with the new gene related to the Parkinson’s disease. From
this research, it is easy to design new therapies to slow neurodegeneration in
the brains of patients with Parkinson’s disease and other related disorders.<span style="font-size: 12.0pt; line-height: 115%;"><o:p></o:p></span></div>
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<span style="font-size: 12.0pt; line-height: 115%;">NFE2L1 is a protein that controls the expression of genes
involved in the differentiation and survival of dopamine neurons. NFE2L1 levels
are reduced in dopamine neurons in the brains of Parkinson’s disease
patients. A large-scale of the genomic
study found that a minor allele of NFE2L1 can lower Parkinson’s risk. These
observations imply that neuron death in Parkinson’s disease may result in part
from a loss of the Neuroprotective action of NFE2L1. It hypothesizes that an
increase of NFE2L1 can alleviate neuron death in rodent models of Parkinson’s
disease. The results of the study will shed light on the ability of NFE2L1 to
reduce neurotoxicity throughout the brain. By increasing NFE2L1 levels in the
brain, it will be developing the Parkinson’s diseases therapies.<o:p></o:p></span></div>
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It creates the new clinical application for
those compounds which increase NFE2L1 levels in the brain, either by
stimulating the protein’s expression or blocking the Protein’s destruction by
the proteasome. NFE2L1 can relieve neuron demise related with alpha-synuclein
amassing and aggregate formation- the trademark pathology of Parkinson's - in
pre-clinical models of Parkinson malady. Alpha-synuclein (also known as
α-synuclein) is a protein whose function is crucial for the healthy brain. It
is of remarkable interest to Parkinson's researchers due to the fact it is a
primary constituent of Lewy bodies, protein clumps which can be the
pathological hallmark of Parkinson's disease.</div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-13357859215650159882018-05-17T22:28:00.002-07:002018-05-17T22:44:12.024-07:00Molecule Prevents Common Cold Virus from Hijacking Human Cells<div dir="ltr" style="text-align: left;" trbidi="on">
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<u><span style="color: #333333; font-size: 14.0pt;">Molecule Prevents Common Cold Virus from Hijacking Human Cells</span></u><u><span style="color: #333333; font-size: 14.0pt; font-weight: normal;"><o:p></o:p></span></u></h1>
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<span style="color: #333333;">Specialists have lab-tried an atom that can battle the normal frosty infection by keeping it from seizing human cells.</span></div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhaaTJmDAD5x_HkRyZdh207_4q5LffOiGvJsq6nwgpvuxXd_trT8AjqvLVMGJhab1H4KOnlgm0T3z8g73EjH0j1S4OnXJKzapfiy-eKXgOyUJmtFOXhetUaCXHmVCM5a6jyYu-7YooPtgc/s1600/BLOG.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="360" data-original-width="640" height="179" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhaaTJmDAD5x_HkRyZdh207_4q5LffOiGvJsq6nwgpvuxXd_trT8AjqvLVMGJhab1H4KOnlgm0T3z8g73EjH0j1S4OnXJKzapfiy-eKXgOyUJmtFOXhetUaCXHmVCM5a6jyYu-7YooPtgc/s320/BLOG.png" width="320" /></a></div>
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<i style="background-color: transparent; text-align: left;"><span style="color: #333333; font-family: "times new roman" , "serif"; font-size: 12.0pt; line-height: 115%;">The novel particle (yellow) pieces human NMT (blue), a protein fundamental for the cool corrupting to gather the geometric capsid 'shell which encases its RNA (green) genome".</span></i></div>
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<span style="color: #333333;">Early lab-based tests with human cells have demonstrated the particle's capacity to totally obstruct various strains of frosty infection, and the group would like to move to creature and after that human trials <o:p></o:p></span></div>
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<span style="color: #333333;">The normal frosty is caused by a group of infections with several variations, making it about difficult to wind up invulnerable to or inoculate against every one of them. Over that, the infections advance quickly, which means they can rapidly pick up protection from drugs. <o:p></o:p></span></div>
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<span style="color: #333333;">Consequently, most chilly cures depend on treating the side effects of the contamination -, for example, runny nose, sore throat and fever - as opposed to handling the infection itself. <o:p></o:p></span></div>
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<span style="color: #333333;">However another atom, created by scientists, targets <i>N-myristoyltransferase (NMT),</i> a protein in human cells. Infections 'capture' <i>NMT</i> from human cells to develop the protein 'shell', or capsid, which ensures the infection genome. <o:p></o:p></span></div>
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<span style="color: #333333;">All strains of the infection require this same human protein to make new duplicates of themselves, so the atom should conflict with every one of them. Furthermore, the particle additionally conflicts with infections identified with the chilly infection, for example, polio and foot and mouth illness infections. <o:p></o:p></span></div>
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<span style="color: #333333;">The particle focuses on a human protein and not simply the infection, making rise of safe infections exceedingly impossible. <o:p></o:p></span></div>
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<span style="color: #333333;">Analyst stated: "The regular cool is a bother for a large portion of us, yet can cause genuine difficulties in individuals with conditions like asthma and <i>COPD</i>. A medication like this could be to a great degree useful if given ahead of schedule in contamination, and we are taking a shot at making a variant that could be breathed in, with the goal that it gets to the lungs rapidly." <o:p></o:p></span></div>
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<span style="color: #333333;">There have been past endeavors to make tranquilizes that objective human cells instead of the infections, however numerous have the symptom of being poisonous. The specialists demonstrated that the new atom totally obstructed a few strains of the infection without influencing human cells. Additionally ponder is expected to ensure it isn't dangerous in the body. <o:p></o:p></span></div>
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<span style="color: #333333;">Specialist stated: "The way the medication works implies that we would should make sure it was being utilized against the chilly infection, and not comparable conditions with various causes, to limit the shot of lethal symptoms." <o:p></o:p></span></div>
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<span style="color: #333333;">The restorative science group were initially searching for aggravates that focused the protein in jungle fever parasites. Screening huge libraries of mixes, they discovered two hits and were shocked to find that they worked best together. <o:p></o:p></span></div>
<span style="color: #333333; font-family: "times new roman" , "serif"; font-size: 12.0pt; line-height: 115%;">By concocting a novel method to consolidate the two, they made a molecule,which is in excess of a hundred times more powerful than past particles focusing on the protein in people.<br />
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-62174955941113592872018-05-10T21:45:00.003-07:002018-05-10T21:45:37.110-07:00<div dir="ltr" style="text-align: left;" trbidi="on">
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<b><u><span style="color: #333333; font-size: 14.0pt;">Particle could enhance memory, lessen Alzheimer's corruption<o:p></o:p></span></u></b></div>
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<span style="color: #333333;">Research that distinguishes a little particle <i>sarco(endo)plasmic reticulum calcium ATPase</i> <a href="https://bioorganic-medicinal.chemistryconferences.org/events-list/structural-and-molecular-biochemistry">SERCA</a> activator that may enhance memory and comprehension. <o:p></o:p></span></div>
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<span style="color: #333333;">In the <i>Alzheimer's</i> ailment models, the SERCA activator demonstrates guarantee in lessening the cell push and avoiding cell misfortune in neurons. The particle redresses cells' calcium particle adjusts and speaks to another helpful technique for neurodegeneration medicate advancement. <o:p></o:p></span></div>
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<span style="color: #333333;">Inquire about have distinguished an intensify that could remedially moderate or stop </span><i style="color: #333333;">Alzheimer's</i><span style="color: #333333;"> illness, while likewise exhibiting its capacity to cross the blood-mind boundary, give great bioavailability and cause no identifiable off-target effects and think about "A New Target for Alzheimer's infection: A Small Molecule SERCA Activator is Neuroprotective in vitro and Improves Memory and Cognition in Mice”.</span></div>
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<span style="color: #333333;">In the examination, investigated how a SERCA activator influences neurodegeneration and basically centered around two subjects, memory/insight and cerebrum cell mass, which are standard in pre-clinical Alzheimer's investigations. <o:p></o:p></span></div>
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<span style="color: #333333;">Research found that their particle saved cerebrum cell mass and helped memory in the treated subjects. The investigation points of interest a variety of tests, including the water labyrinth test for memory, and shows the SERCA activator particle's ability for neuroprotection. <o:p></o:p></span></div>
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<span style="color: #333333;">Our concentration is making atoms that achieve their objective and go about as a defender against cell damage. Research said at present, there are no medications affirmed that in reality back off or stop neurodegeneration. Our definitive item would achieve this accomplishment and convey the solution to centers.<o:p></o:p></span></div>
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<span style="color: #333333;">In a past report, the SERCA activator likewise created a 60 percent diminishment in Alzheimer's mind plaques, an eventual outcome of treatment. The present examination additionally approves these outcomes by demonstrating that the atom likewise treats common Alzheimer's indications. <o:p></o:p></span></div>
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<span style="color: #333333;">Research could at long last have a treatment altering Alzheimer's illness and this particle can save cells from apoptosis, or cell demise. Forestalling cell passing can likewise avoid additionally mind decay and memory misfortune going with the infection.<o:p></o:p></span></div>
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<span style="color: #333333;"><a href="https://bioorganic-medicinal.chemistryconferences.org/abstract-submission.php">Neurodon</a> is a startup, moving in the direction of finding neuroprotective medications. inquire about medicines to various cell demise sicknesses, for example, Alzheimer's ailments and amyotrophic parallel sclerosis (ALS). <o:p></o:p></span></div>
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<span style="color: #333333;">Next, Neurodon advances to preclinical testing and, in the long run, to build up an oral pill treating neurodegeneration.<o:p></o:p></span></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-91513284369122224512018-05-03T22:18:00.000-07:002018-05-03T22:18:06.279-07:00Drug strategy to block tau transmission<div dir="ltr" style="text-align: left;" trbidi="on">
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<b><span style="color: #333333; font-family: "Times New Roman","serif"; font-size: 14.0pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-IN; mso-font-kerning: 18.0pt;">Drug strategy to block tau transmission<o:p></o:p></span></b></div>
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<i><span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 115%;">Alzheimer'</span></i><span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 115%;">s illness pulverizes cerebrum cells to some extent by advancing the development of insoluble bunches that contain a protein called tau. Not exclusively are these <i>"tau totals"</i> lethal for the phones that harbor them, however they likewise attack and obliterate neighboring mind cells, or neurons, which speeds the intellectual decay related with the Alzheimer's. <o:p></o:p></span></div>
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<span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 115%;">Hence, Alzheimer's specialists have been strongly keen on treatments went for either counteracting tau conglomeration or obstructing its spread. <o:p></o:p></span></div>
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<span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 115%;">Presently, analysts have revealed a promising medication system that pieces tau transmission. Utilizing refined cells, mouse models and protein auxiliary investigation, the scientists found that a little atom called <i>cambinol </i>obstructs the exchange of tau totals from cell to cell. The examination could help lay the foundation for treatments to treat Alzheimer's or different dementias related with the collection of tau. <o:p></o:p></span></div>
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<span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 115%;">"More than 200 atoms have been tried as ailment adjusting Alzheimer's treatment in clinical trials, and none has yet accomplished the blessed chalice," said scientist. <o:p></o:p></span></div>
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<span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 115%;">In sound individuals, tau proteins are amiable building squares of a neuron's system, or cytoskeleton. In any case, in Alzheimer's illness, tau proteins fall far from the cytoskeleton, turn out to be unusually adjusted, and afterward frame insoluble "neurofibrillary tangles" that crush cells. To exacerbate the situation, kicking the bucket cells encase tau totals in lipid vesicles called <i>exosomes</i>, which at that point bud off and "seed" neighboring tissues, keeping the ruinous cycle going. <o:p></o:p></span></div>
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<span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 115%;">The specialists led a few examinations that propose that <i>cambinol</i> can subvert the "exchange" advance by obstructing a chemical called nSMase2, which is basic for catalyzing generation of the exosome transporters. In one, the researchers utilized "contributor cells" that harbored tau totals got from after death human Alzheimer's examples and blended them with sans tau beneficiary cells. <o:p></o:p></span></div>
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<span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 115%;">Without cambinol, the totals spread from givers to beneficiaries, reflecting what occurs in the brains of individuals with Alzheimer's. Be that as it may, when treated with cambinol, beneficiary cells remained without tau when developed one next to the other with tau-positive contributors, probably in light of the fact that the medication incapacitated nSMase2 movement blocking arrival of the tau-conveying exosomes. <o:p></o:p></span></div>
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<span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 115%;">The analysts likewise watched diminished nSMase2 synergist movement in the brains of mice that were given cambinol orally.<o:p></o:p></span></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-6459743669112110092018-04-27T21:31:00.001-07:002018-04-27T21:31:31.843-07:00Nanomedicine: Drugs Can Be Made ‘Smarter' Using New Drug Design Technology<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="color: #222222; font-size: 14.0pt;">Nanomedicine: Drugs Can Be Made ‘Smarter' Using New Drug Design Technology<o:p></o:p></span></h1>
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<span style="font-family: "times new roman" , "serif"; font-size: 12.0pt; line-height: 115%;">Another technique has been created to make drugs 'more quick witted' utilizing nanotechnology so they will be more successful at achieving their objective. <o:p></o:p></span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: 12.0pt; line-height: 115%;">Researchers have formulated another method to 'beautify' gold nanoparticles with a protein of decision so they can be utilized to tailor medication to all the more precisely focus on a region on the body, for example, a growth tumor. <o:p></o:p></span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: 12.0pt; line-height: 115%;">Gold nanoparticles are circles made of gold iotas having a distance across of just couple of billionths of a meter which can be covered with a natural protein and joined with medications to empower the treatment to movement through the body and achieve the influenced region. <o:p></o:p></span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: 12.0pt; line-height: 115%;">The nanoparticles can 'adsorb' (hang on its surface) drugs which would some way or another wind up insoluble or rapidly corrupt in the circulation system, and because of their little size they can beat natural boundaries, for example, layers, skin and the small digestive tract which would as a rule keep the medication from achieving its objective. <o:p></o:p></span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: 12.0pt; line-height: 115%;">The innovation is now utilized as a part of genuine applications, for example, pregnancy tests where gold nanoparticles improved with a counter acting agent against the hormone show in the pee of pregnant ladies is added to the 'positive' strip so it responds with the nanoparticles to turn the stick red – yet isn't yet generally utilized as a part of medication advancement. <o:p></o:p></span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: 12.0pt; line-height: 115%;">As of recently the way toward covering the nanoparticles implied that the proteins utilized must be combined with particles which don't be able to control the way they tie, perhaps making the medication less successful. The new strategy empowers pharmacologists to put the proteins onto the gold nanoparticles layer by layer in a particular request. This keeps up the uprightness of the protein with the goal that the medication is more compelling, opening up conceivable outcomes for the advancement of nanomedicine. <o:p></o:p></span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: 12.0pt; line-height: 115%;">A nanobiotechnologist from the University drove the investigation. They stated: "Gold nanoparticles are an essential apparatus in new medication advancement and medication conveyance frameworks. We have opened the way to restricting proteins and atoms with the goal that those medications will be more viable. "This technique may plan nanomedicines that don't require broad compound change of a protein tranquilize or a nano-bearer and along these lines can be produced all the more effectively and quicker." <o:p></o:p></span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: 12.0pt; line-height: 115%;">Specialists took parts of proteins from microbes and flatworms, which when combined were compelling at authoritative to the gold nanoparticle surface and ready to shape stable bonds to some other protein. <o:p></o:p></span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: 12.0pt; line-height: 115%;">By blending this combination protein with gold nanoparticles, it for all time ties to the gold surface while likewise having the capacity to steadily tie an objective protein on which a particular 'tag' was incorporated. <o:p></o:p></span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: 12.0pt; line-height: 115%;">This is another widespread strategy to tie proteins to nanoparticles which will work for most proteins, making the procedure a more appealing prospect for pharmaceutical organizations, the specialists said. <o:p></o:p></span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: 12.0pt; line-height: 115%;">The strategy could likewise conceivably be connected to biosensors and analytic packs that utilization gold, for example, those utilized as a part of clinical settings to distinguish progressing contaminations in patients' blood.<o:p></o:p></span></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-28989814385965690252018-04-20T04:02:00.000-07:002018-04-20T04:02:14.991-07:00Blocking Protein Helps Prevent Heart Attack Scars<div dir="ltr" style="text-align: left;" trbidi="on">
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<b><span style="color: #333333; font-family: "Times New Roman","serif"; font-size: 16.0pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-IN; mso-font-kerning: 18.0pt;">Blocking Protein Helps Prevent Heart Attack Scars</span></b><span style="color: #333333; font-family: "Times New Roman","serif"; font-size: 16.0pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-IN; mso-font-kerning: 18.0pt;"><o:p></o:p></span></div>
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<span style="background: white; color: #333333; font-family: "Times New Roman","serif"; font-size: 14.0pt; line-height: 115%;">Researchers utilized a trial focused on atomic treatment to obstruct a grid framing protein in heart cells harmed by heart assault, diminishing levels of scarred muscle tissue and sparing mouse models from heart disappointment.<o:p></o:p></span></div>
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<span style="background: white; color: #333333; font-family: "Times New Roman","serif"; font-size: 14.0pt; line-height: 115%;">They tried a fabricated peptide called pUR4 to obstruct the fibronectin protein in human heart cells gave by heart disappointment patients. The treatment kept the human heart cells from falling flat and reestablished their capacity. The treatment additionally diminished fibrosis and enhanced heart work after a recreated heart assault in mice.<o:p></o:p></span></div>
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<span style="background: white; color: #333333; font-family: "Times New Roman","serif"; font-size: 14.0pt; line-height: 115%;">Fibronectin is regularly a decent on-screen character in the body. It helps shape a cell-supporting lattice for the body's connective tissues, helping tissue repair after damage.<o:p></o:p></span></div>
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<em><span style="background: white; color: #333333; font-family: "Helvetica","sans-serif"; font-size: 10.5pt; line-height: 115%;">This microscopic image shows fibrotic heart cells from a patient who had heart failure. The cells have an elaborate fibronectin matrix (shown in red) which causes fibrosis and heart damage. Credit: Cincinnati Children's<o:p></o:p></span></em></div>
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<span style="background: white; color: #333333; font-family: "Times New Roman","serif"; font-size: 14.0pt; line-height: 115%;">However, after a heart assault, fibronectin blows up, polymerizes and helps deliver excessively connective lattice. It additionally causes hyperactive generation of stopped up and useless cardio myofibroblast cells that harm the heart. The pUR4 compound is composed so it will join to surface focuses on fibronectin, adequately hindering its belongings in harmed heart cells.<o:p></o:p></span></div>
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<span style="background: white; color: #333333; font-family: "Times New Roman","serif"; font-size: 14.0pt; line-height: 115%;">A key inquiry in the present Circulation contemplate was checking the consequences of pUR4 focused on sub-atomic treatment in both the mouse models and human heart disappointment cells. In mice with reproduced heart assault that as a control analyze got a fake treatment, the creatures created noteworthy fibrosis and heart disappointment. At the point when analysts treated mice with pUR4 for simply the initial seven days after heart assault, or hereditarily erased fibronectin action from the heart cells of mice, these lessened fibrosis and enhanced cardiovascular capacity. Treatment of human falling flat heart cells with pUR4 likewise decreased their fibrotic conduct.<o:p></o:p></span></div>
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<span style="background: white; color: #333333; font-family: "Times New Roman","serif"; font-size: 14.0pt; line-height: 115%;">The scientists underline it's too soon to know whether the trial treatment in this investigation would one be able to day be utilized to treat human heart patients clinically<o:p></o:p></span></div>
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<span style="background: white; color: #333333; font-family: "Times New Roman","serif"; font-size: 14.0pt; line-height: 115%;">Specialists additionally are attempting to refine the pUR4 peptide to improve its abilities for restricted organization to the heart and for expanded discharge in patients.<o:p></o:p></span></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-1710877120382869792018-04-07T00:06:00.003-07:002018-04-07T00:06:49.128-07:00Functionalized Carbon Nanotubes in Drug Design and Discovery<div dir="ltr" style="text-align: left;" trbidi="on">
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<span class="hlfld-title"><span style="font-size: 14pt;">Functionalized Carbon Nanotubes in Drug Design and Discovery</span></span></h1>
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<span style="background-color: white; font-size: 12pt; text-align: justify;">Carbon nanotubes (CNTs) have been proposed and effectively investigated as multipurpose inventive bearers for </span>tranquilize<span style="background-color: white; font-size: 12pt; text-align: justify;"> conveyance and indicative applications. Their flexible physicochemical highlights empower the covalent and noncovalent presentation of a few pharmaceutically significant substances and take into consideration balanced outline of novel competitor nanoscale builds for tranquilize improvement. CNTs can be functionalized with various practical gatherings to convey all the while a few moieties for focusing on, imaging, and treatment. Among the most fascinating cases of such multimodal CNT develops depicted in this Account is one conveying a fluorescein test together with the antifungal medication amphotericin B or fluorescein and the antitumor operator methotrexate. The natural activity of the medication in these cases is held or, as on account of amphotericin B builds, upgraded, while CNTs can diminish the undesirable poisonous quality of the medication managed alone. Ammonium-functionalized CNTs can likewise be viewed as extremely encouraging vectors for quality encoding nucleic acids. Surely, we have framed stable buildings between cationic CNTs and plasmid DNA and showed the upgrade of the quality restorative limit in contrast with DNA alone. Then again, CNTs conjugated with antigenic peptides can be produced as another and powerful framework for engineered immunization applications. What makes CNTs very one of a kind is their capacity, first appeared by our gatherings in 2004, to latently cross films of a wide range of sorts of cells following a translocation system that has been named the nanoneedle component. In that way, CNTs open countless conceivable outcomes for future medication disclosure in light of intracellular focuses on that have been difficult to reach until today. Besides, enough functionalized CNTs as those appeared in this Account can be quickly dispensed with from the body following foundational organization offering further </span>encouragment<span style="background-color: white; font-size: 12pt; text-align: justify;"> for their improvement. CNT discharge rates and aggregation in organs and any reactivity with the insusceptible framework will decide the CNT security profile and, therefore, any further pharmaceutical advancement. Alert is prompted about the requirement for deliberate information on the long haul destiny of these extremely fascinating and flexible nano-protests in </span>relationship<span style="background-color: white; font-size: 12pt; text-align: justify;"> with the kind of CNT material utilized. CNTs </span>are bit<span style="background-color: white; font-size: 12pt; text-align: justify;"> by bit </span>plyaing<span style="background-color: white; font-size: 12pt; text-align: justify;"> a greater and more essential part in the rising field of nanomedicine; in any case, we have to ensure that the immense open doors they offer will be converted into attainable and safe builds to be incorporated into tranquilize disclosure and improvement pipelines.</span></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0tag:blogger.com,1999:blog-1418356858135207183.post-42234503229172926162018-04-03T01:30:00.000-07:002018-04-03T01:30:21.697-07:00Recent Trends in Photoaffinity Labeling<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="background: white; color: #222222; font-family: "Times","serif"; font-size: 13.0pt; letter-spacing: .15pt; line-height: 115%;">Examination of receptor—ligand communications remains a boundless test for physicists and scientists. Auxiliary investigation of natural receptors is the beginning stage for a superior comprehension of how they work. Photoaffinity marking is a biochemical way to deal with recognize and describe receptors focusing on advance auxiliary examinations. The essential structure of a receptor protein was commonly acquired by turn around hereditary qualities after thorough sanitization and sequencing of the N</span><span style="background: white; color: #222222; font-family: "Cambria Math","serif"; font-size: 13.0pt; letter-spacing: .15pt; line-height: 115%; mso-bidi-font-family: "Cambria Math";">‐</span><span style="background: white; color: #222222; font-family: "Times","serif"; font-size: 13.0pt; letter-spacing: .15pt; line-height: 115%;">terminal peptide, which permitted the outline of the comparing oligonucleotide tests. Blend of these oligonucleotide tests at that point prompted distinguishing proof of cDNA clones by hybridization. Following this methodology, a few layer neurotransmitter receptors and constituent polypeptides, display in little amounts in the focal sensory system, were distinguished and their arrangement found from the cDNA succession. Since photoaffinity naming suggests the development of a covalent bond between a radiolabeled ligand simple and a receptor restricting site, it turns out to be hypothetically conceivable to seclude and arrangement radiolabeled peptides and after that incorporate the relating oligonucleotide tests. Photoaffinity naming may maintain a strategic distance from the basic solubilization and filtration ventures of the traditional approach. As far as anyone is concerned, no such case of essential structure assurance in light of photoaffinity marking tests has been accounted for. In any case, the phenomenal improvements in quality cloning advances, specifically homology cloning and articulation cloning, have made this approach old and brought up the issue of new points of view for photoaffinity marking innovation. In this article we display a report on chose unique improvements, and additionally new difficulties for this strategy. Photoaffinity marking offers access to auxiliary components as well as a potential instrument for the examination of practical parts of organic receptors, for instance their part in flag transduction systems.<o:p></o:p></span></div>
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Bioorganic Medicinal 2019http://www.blogger.com/profile/03294760802074984243noreply@blogger.com0